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Miranda Rights.  Complete the Miranda Rights with the correct words and translate those words in English. Number your answers. Choose from: abogado (2x) – hablar – silencio – diga – comprende – justicia – derecho (2x)  – contra Tiene __________(1) a permanecer en ____________(2) Cualquier cosa que _________(3) puede ser usada en su __________(4) en un tribunal de ______________(5). Tiene ____________(6) a un ____________ (7) durante el interrogatorio. Si no puede pagar un ___________(8), se le asignará uno. ¿ _________________ (9) los derechos que le acabo de leer? Teniendo estos derechos en cuenta, ¿ desea ____________(10) conmigo?

The following molecules all bind to the same receptor. Which would have lowest entropic cost of binding?         

Rational drug design relies on what kind of information or materials for success?

Sulfur substitution for carbon or oxygen often lowers the Kd of a molecule due its more effective:

4)  What is the best explanation for the relative Kd values of molecules 1-3?

In early research on the muscarinic cholinergic system, for what purpose were the following acetylcholine analogs prepared?                

Which of the following phenols is the strongest acid?                    

para-fluorophenol will have a pKa that is higher or lower than phenol?

Consider the following reaction catalyzed by an esterase that is a therapeutic target. Which of the reaction species above (0 through 3) is likely to have the most energetically favorable interactions with amino acids in the enzyme active site?                

Consider a molecule A that has 3 chiral centers. How many diastereomers exist for A? think carefully.