Suppose we have the counts of A, T, C, G in chromosome 1 of…

Suppose we have the counts of A, T, C, G in chromosome 1 of some individual. Denote them by  nA, nT, nC, nG.  Our goal is to check whether the A-T and C-G base pairing rule exists in human genome by hypothesis testing. Which of the following is the best choice for the test statistic? (Note that |x| denotes the absolute value of x.)