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A 55-year-old male presents with fatigue, weight loss, and pruritus. Laboratory studies reveal leukocytosis, elevated basophils with immature forms on a peripheral smear, >20% basophilic blasts in the bone marrow, and elevated serum histamine levels. What best explains the relationship between hyperhistaminemia and the patient’s condition?

A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso. Patient history was unremarkable. Physical examination revealed a palpable liver and spleen.  CBCo   WBC count: 72  × 109/Lo   Hb: 8.7 g/dL o   Hct: 25% o   Normal indices o   PLT count: 55 × 109/L Differential: 40% blasts, 30% promyelocytes, 10% myelocytes, 4% metamyelocytes, 5% bands, 11% segemented neutrophils  Cytogenetics have been ordered – what abnormality is likely to be detected?   

The WHO generally defines acute lymphoblastic leukemia as having a blast count that is which of the following?

A patient presents with a morphological smear examination revealing >20% blasts with prominent granules and Auer rods. A 25% monocyte count was seen in the peripheral smear. There were no recurrent cytogenetic abnormalities observed. Under which classification of acute leukemia, not otherwise specific, does this diagnosis fall?

An adult patient presents with 44% blasts. The blasts are monomorphic, with abundant basophilic cytoplasm. The majority of blasts show prominent vacuolization (shown below). Cytogenetics shows translocation of the MYC gene (8q24) to the IgH chain locus [t(8;14)]. What is the diagnosis?

Which markers are useful in immunophenotyping for leukemia/lymphoma of T cell-lineage?

What is the cornerstone of treatment for Acute Promyelocytic Leukemia (APL)?

A patient with social anxiety disorder uses propranolol before public speaking. How does this medication alleviate performance anxiety symptoms?

Match the following mechanisms of action with the appropriate medications.

You are working in a hospital and have been asked to perform the LAL test (Limulus amebocyte lysate). After adding the amebocytes from the horseshoe crab to the serum, coagulation is observed. What conclusion can you draw from this?