The majority of genetic defects in humans that cause autoimm…

The majority of genetic defects in humans that cause autoimmune diseases are in genes that regulate T cell responses. These include the AIRE, CTLA4, FOXP3, and FAS genes. These findings indicate that B cells and innate immune cells are not important in autoimmunity.

The prevention of inflammatory immune responses to inhaled a…

The prevention of inflammatory immune responses to inhaled antigens in healthy individuals has mechanisms in common with those that prevent inflammatory immune responses to commensal microbes in the gut. One important component of immune regulation shared by these two situations is: