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The clearance of ibuprofen is 4 L/hr and its apparent volume of distribution (V) is 12 liters.  If 800 mg of ibuprofen were administered every 12 hours, what would be the steady-state trough plasma concentration (mg/L)?  Assume rapid and complete absorption that approximates i.v. bolus administration.

Predict the plasma concentration (mg/L) 3 hours after an oral dose of drug A.  Drug A has the following parameters: Dose = 200 mg F= 0.80 ka = 0.78 hr-1 KE = 0.120 hr-1 V = 50 L

For Low E drugs hepatic clearance is least sensitive to changes in 

The elimination rate constant (KE) can be calculated from

Drug A is renally eliminated with an ERATIO of 2.1. Additionally, changes in urine pH result in changes in the total renal clearance.  Based on this information which processes must be involved in the clearance of Drug A?

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Nexium V = 16 L CLH = 120 ml/min fup = 0.03 Normal Dose is 40 mg daily by mouth (assume all of the drug absorbs and there is no metabolism in the gut) Determine the average steady-state total concentration (mg/L) in a patient with a polymorphism in the CYP2C19 enzyme such that CLint,u is 50% of normal.

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In divergence

This type of receptor responds to changes in chemical concentrations.