Blog

In early research on the muscarinic cholinergic system, for what purpose were the following acetylcholine analogs prepared?                

Which of the following phenols is the strongest acid?                    

para-fluorophenol will have a pKa that is higher or lower than phenol?

Consider the following reaction catalyzed by an esterase that is a therapeutic target. Which of the reaction species above (0 through 3) is likely to have the most energetically favorable interactions with amino acids in the enzyme active site?                

Consider a molecule A that has 3 chiral centers. How many diastereomers exist for A? think carefully. 

Which of the following analogs of A contains a bioisosteric substitution?

60.  You are in charge of administering a screening test to a large population.  a). under what circumstances would you want to minimize false positive results (name 2 circumstances ONLY). b).  under what circumstances would you want to minimize the false negatives (2 circumstances ONLY).

Which structure is depicted by #2

Identify the writer of the following work: “The Purloined Letter”

Unlike Poe or Dickinson, Whitman was quite involved in the political scene of his time.