A 68-year-old female admitted for congestive heart failure i…

A 68-year-old female admitted for congestive heart failure is in respiratory distress and is being seen by the hospital’s medical emergency team in her regular room. The patient is in obvious respiratory distress and is immediately placed on a nonrebreather mask. Physical assessment reveals: pulse 138 and thready; respiratory rate 28, shallow and labored; temperature 37° C; blood pressure 110/68. Breath sounds are bilaterally decreased with coarse crackles on inspiration. EKG shows normal sinus rhythm with widened cardiac output (QT) interval and an occasional irregular beat. No coughing is noted. The arterial blood gas on the nonrebreather mask is: pH 7.34; PCO2 46 mm Hg; partial pressure of oxygen in the arteries (PaO2) is 52 mm Hg; oxygen saturation is 86%; bicarbonate (HCO3-) is 24 mEq/L. The patient is diaphoretic. The most appropriate ventilator mode to manage this patient initially is which of the following?

A patient with acute respiratory distress syndrome (ARDS) ha…

A patient with acute respiratory distress syndrome (ARDS) has developed a pneumothorax from elevating peak and plateau pressures. The patient is currently being ventilated in the volume-controlled continuous mandatory ventilation (VC-CMV) mode with a set rate of 12 breaths/min. However, the patient is triggering the ventilator at a rate of 25 breaths/min. The arterial blood gas reveals ventilator-induced hyperventilation with corrected hypoxemia. The most appropriate recommendation to manage this patient on the ventilator is which of the following?

Genetic defects in lysosomes cause lysosomal storage disease…

Genetic defects in lysosomes cause lysosomal storage diseases (LSDs), a group of rare inherited metabolic disorders that can result in missing or insufficient enzymes in the lysosome. Predict what kinds of issues or problems individuals with LSDs might have based on your understanding of lysosomal function.