38-year-old woman is being evaluated for treatment of severe…

38-year-old woman is being evaluated for treatment of severe irritable bowel syndrome with diarrhea (IBS-D). The provider is considering prescribing alosetron. Which of the following findings would most likely contraindicated the use of alosetron in this patient with knowing the black box warning causing ischemic colitis?  

A 52-year-old woman was diagnosed with active pulmonary tube…

A 52-year-old woman was diagnosed with active pulmonary tuberculosis and started on a standard first-line regimen including isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB). After several months of therapy, her sputum cultures remain positive for Mycobacterium tuberculosis, indicating treatment failure. Drug susceptibility testing reveals resistance to multiple first-line agents. Which of the following is the most appropriate next step in her treatment?