Pyrazinamide is associated with the following drug interacti…

Pyrazinamide is associated with the following drug interactions:                                    1.        Decreases hepatic metabolism of warfarin2.       Decreases the effectiveness of oral contraceptives 3.        Dosage adjustment of allopurinol necessary since pyrazinamide decreases renal          urate clearance 4.       Decreases metabolism of alcohol5.       Decreases the blood levels of nevirapine

Pyrazinamide is associated with the following drug interacti…

Pyrazinamide is associated with the following drug interactions:                                             1.   Decreases hepatic metabolism of warfarin; dosage adjustment is necessary2.   Decreases the effectiveness of oral contraceptives by enhancing their metabolism 3.   Decreases urate clearance, thus dosage adjustment of antigout agents necessary4.   Decreases metabolism of alcohol, concomitant use is best avoided5.   Decreases the blood levels of nevirapine, concurrent use is best avoided

Emtricitabine should not be withdrawn in patients with HIV a…

Emtricitabine should not be withdrawn in patients with HIV and hepatitis B  virus coinfection for the following reasons:                                                   1. There is a risk of bone marrow suppression                                                               2. There is a risk of rebound hepatitis.                                                                                                         3. There is a risk of hypersensitivity reactions                                                                                          4. There is a risk of decreased bone density                                                                                             5. There is a risk of uncontrolled diabetes mellitus