A 32-year-old man has a 3-months history of nervousness, tre…

A 32-year-old man has a 3-months history of nervousness, tremors, palpitation, increased sweating and discomfort with heat. He had lost 15 lbs despite increase food intake. He also noted muscle weakness and easy fatigability with exercise to which he was ordinarily accustomed. His skin was warm and moist, speech is rapid, his gaze had a stare quality (shown below) , and his  movements were hyperkinetic. He exhibited tremors and very rapid reflexes, and he was unable to rise without assistant from a squatting position. Which one the following test result would confirm his medical condition?  

Infantile Tay-Saches disease is characterized by relentless…

Infantile Tay-Saches disease is characterized by relentless deterioration of mental and physical abilities. It is caused by genetic mutation of HEXA gene coding for a vital hydrolase enzyme What do you expect about the localization of this hydrolase enzyme?

A 32-year-old woman presents with joint stiffness and pain o…

A 32-year-old woman presents with joint stiffness and pain of the hands and wrists for the last two years. Her symptoms are most severe in the morning and improve in the afternoon. She reports an unintentional loss of 15 pounds over the course of 3 months as well as fatigue. On physical exam, there is swelling and tenderness at the metacarpophalangeal and proximal interphalangeal joints. What is the most probable cause of her condtion?