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Listed below are several statements regarding treatments of sleep disorders. Which of the following statements is CORRECT?

Of the following medications, which would predict to be the LEAST appropriate in treating a 55 yo Asian female with neuropathic pain due to post-herpetic neuralgia? This patient is also currently receiving chronic oxycodone for treatment of her left hip osteoarthritis. She lists her only allergy is to carbamazepine (rash). (SELECT ALL THAT APPLY)

A 19-year-old patient, newly diagnosed with schizophrenia, is hospitalized with symptoms including auditory hallucinations, delusions, and disorganized speech. No suicidal ideation. The physician recommends starting an antipsychotic. The patient’s parents worry about his ability to take medication daily. He has a BMI in the obese range, smokes one pack of cigarettes daily at home, and has no other medical conditions or medications. Which of the following statements is TRUE regarding his treatment?

JH is a 47-year-old male who comes into the clinic today and tells the medical team that over the past few months he has experienced worsening in the symptoms in his legs.  He describes a creepy crawly feeling that appears in the evening and worsens around bedtime.  It gives the patient difficulty falling asleep.  He is diagnosed with restless legs syndrome and the medical team would like your help in choosing medication therapies. His ferritin levels are given below: Today –      Ferritin: 26 ng/mL   Based on RLS treatment guidelines, what would be the recommendation would you make for JH’s drug therapy?

Which of the following CYP isozymes does not seem to show clear genetic polymorphisms that lead to clear clinical phenotypes in drug response/effect?

A local Dentist call you because he is worried about using Tylenol with Codeine in a patient who is a CYP2D6 Ultra Metabolizer. You feel the MOST appropriate response back would be:

PL is a 46 y/o man with post-herpetic neuralgia (PHN).  TM has tried several medications for his PHN, including gabapentin and ibuprofen, with little success.  He is calling you today to ask your advice regarding other treatment options.  Which of the following would be the MOST reasonable next option for this patient?

You are consulted on 19 yo male patient with partial onset epilepsy who the physician wishes to start on an antiseizure medication. The patients mother recently paid to have a 23&Me gene panel run on her child. The results suggested that he is a CYP2C19 PM. The physician is worried about a potential drug-gene interaction. Which of the following drugs would you be MOST concerned about?

A 28 yo male patient with a diagnosis of bipolar disorder is admitted to the hospital during a manic episode. He is not taking medication upon admission and does not have other medical conditions. Which of the following are first-line medications for treating mania in this patient? (SELECT ALL THAT APPLY)

A card is drawn randomly from a standard 52-card deck. Find the probability of the given event.(c) The card drawn is not a face card.The probability is :_________________*Type your answer as a decimal, round to the nearest 4 decimals.