A colleague approaches you, their neighborhood structural bi…

A colleague approaches you, their neighborhood structural biologist, stating that they discovered a receptor-ligand pair that is essential for alligator reproduction. They used Alphfold to generate a 3D model of the receptor alone, ligand alone, and receptor-ligand complex, but they don’t know how to interpret the data. What scoring metrics would you consult to determine whether the structural models are reliable? Are these metrics different for the receptor alone versus the receptor-ligand complex?

Unless otherwise stated by exam instructions or official acc…

Unless otherwise stated by exam instructions or official accommodations are in place, I understand that any and all electronic devices including but not limited to, cell phones, iPad/tablet, digital/smart watches, second monitors, or other electronic devices are not allowed to be used or out during the exam. The only exception is having my course notes on a iPad/tablet, which I will keep in view of my webcam so that proctors can see I’m only using it to look up already stored information, not accessing online searches, using artificial intelligence, or communicating with others.

Senile plaques and neurofibrillary tangles are the two hallm…

Senile plaques and neurofibrillary tangles are the two hallmark pathologies of Alzheimer’s disease. Name the major protein composition of plaques and tangles. Describe how these pathologies form in the brain and discuss how disease pathology may propagate in the brain.