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the supernatant of centrifuged whole blood to which an anticoagulant (EDTA or heparin) has been added defines

What is the relationship between the volume of distribution and the elimination rate constant?

If a 100 mg i.v. dose produced an 800 µg (microgram)/L plasma concentration (Cp,0), what concentration would result from a 200 mg dose? (1 mg = 1000 micrograms)

I would like 5 free points to start the exam.

After administration of a drug, the concentration is the same in every tissue.

For a very lipophilic drug what would you predict would happen to the volume of distribution in an obese individual as compared to a non-obese individual?

What determines a drug’s volume of distribution?

To determine the volume of distribution we need to know

How can the volume of distribution of a drug exceed the total fluid volume of the body?

The size of the space into which a drug appears to distribute in the body.