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You review a 78-year-old man at your GP surgery. His daughte…

You review a 78-year-old man at your GP surgery. His daughter reports a stepwise deterioration in his memory and ability to look after himself and is worried he has Alzheimer’s disease. His PMH includes a transient ischaemic attack (TIA) last year and hypertension. He smokes 10 cigarettes per day and receives a hydroxocobalamin injection every 3 months for vitamin B12 Blood pressure is 180/75 mmHg. His neurological examination is unremarkable. He scores 8/30 on the mini-mental state examination (MMSE) with relative preservation of short-term memory. A CT head shows small vessel disease only. Routine bloods are normal except; chronically raised potassium (5.2 mmol/L) which has been extensively investigated and no cause found. A blood vitamin B12 level is 205 μg/mL (normal range 200 μg/mL – 500 μg/mL). Which of the following as a pharmacist would you consider as the MOST appropriate treatment option with regard to his cognitive impairment?

A 19-year-old woman has presented to hospital with signs of…

A 19-year-old woman has presented to hospital with signs of agitation, tremor, tachycardia, confusion and hallucinations. Past medical history: Depression, migraine. Drug history: Sumatriptan when required, Paroxetine 20mg daily (started 1 week before admission). She is thought to have taken an overdose of paroxetine (approximately 10 tablets) following an argument with her parent. Which of the following is the likely diagnosis relating to her symptoms?