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Refer to the structures shown here for the following questions: *** a) Which TWO sugars could be described as DISACCHARIDES? [blank3] *** b) An oral dose of sucrose is converted to two monosaccharides called : [blank4] *** c) The conversion of sucrose into two monosaccharides occurs where in the body?: [blank5]

The monosaccharide components of table sugar (sucrose) and high-fructose corn syrup (HFCS) are chemically …

What is the distinction between log P and p?

Allulose is structurally similar to which artificial sweetener? ​   Pro-Tyr-Arg-Glu-Asp-Lys-Cys-Lys-Lys-Val-Tyr-Glu-Asn-Tyr-Pro-Val-Ser-Lys-Cys-Gln-Leu-Ala-Asn-Gln-Cys-Asn-Tyr-Asp-Cys-Lys-Leu-Asp-Lys-His-Ala-Arg-Ser-Gly-Glu-Cys-Phe-Tyr-Asp-Glu-Lys-Arg-Asn-Leu-Gln-Cys-Ile-Cys-Asp-Tyr-Cys-Glu-Tyr aspartame steviol fructose brazzein

Given the following log P values, what is the predicted log P value for the disubstituted structure?  

Match the substances on the right to the things they are obtained from, listed on the left.

Which of the following reflects the order in which various stages of the drug discovery and development take place?

Natural products are often used as lead compounds in the design and synthesis of novel drugs. Which of the following general characteristics of a natural product is most likely to be a disadvantage in synthesising analogues?

According to ‘Lipinski’s Rule of 5’, a compound intended for oral administration should have a molecular weight less than: [blank1]

ADRENERICS… Consider the structures shown here for the questions below: *** a)  Define the term AGONIST: [blank1] *** b) Define the term ANTAGONIST: [blank2]  *** c) Drug (ii) is called albuterol and is used to treat the respiratory disease known as asthma. Albuterol is an agonist that binds in a similar manner compared to an endogenous neurotransmitter, compound (i.). Name compound (i.) [blank3] *** d)  Drug (iii) is called propranolol and it is an antagonist compared to compound (i.). Briefly describe the pharmacophore common to all three structures (i. ii. and iii.) [blank4] *** e) Briefly, how do the varying structures shown above lead to their agonist or antagonist activity? [blank5] *** f)  Rank the drugs in order from most water soluble to least water soluble: [blank6] Structure (i.) is a “Catecholamine”, where the catechol portion is circled in the figure below. It undergoes metabolism to an inactive compound. *** g) Provide a generic name for an enzyme that could complete this metabolic reaction. [blank7]