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If you transfected cells with an expression plasmid encoding a dominant-negative mutant of calreticulin, how do you predict it would affect global translation rates in those cells?

Which of the following microtubules are attached to chromosomes?

What is the predicted fate of lysosomal acid hydrolases in cells lacking the enzyme required for the formation of mannose-6-phosphate residues?

Which lipid(s) is(are) synthesized in the Golgi apparatus?

When most myosins, such as Myosin I and Myosin V, drive organelle transport, what direction do they move?

Intermediate filaments are particularly important in nerve cells because they?

During the unfolded protein response, if IRE1 ribonuclease activity excised a 27-nucleotide stretch out of the XBP1 mRNA instead of a 26-nucleotide stretch, how do you predict it would impact the resulting XBP1 protein’s contribution to cell’s response?

What effect would the addition of a lysosome-targeting signal have on the subcellular localization of a protein that is normally cytosolic?

Lysosomes contain powerful hydrolytic enzymes, which are transported there from their site of synthesis in the ER via the Golgi apparatus. Why don’t these enzymes damage the constituents of these organelles?

What is the function of karyopherins?