Blog

In 2018, a genome-wide association study for major depressive disorder (MDD) was published in the journal Nature Communications. The first Manhattan plot below is from that publication. In this study, genome-wide significant SNPs had a P  7.3, and the cutoff for suggestive SNPs was P=10−6 [-Log10(6)].   1) How many independent loci are associated with MDD at a genome-wide significance level in the 2018 GWAS? [2] 2) If the only difference between these two studies is sample size, which GWAS has the biggest sample size? [2019] 3) If the only difference between these two studies is sample size, do the genome-wide significant variants identified in the 2018 study have a bigger or smaller effect size than most of the genome-wide significant variants identified in the 2019 study? [bigger]

Which characteristic distinguishes Huntington’s Disease from other diseases?

The AV Node is the heart’s original ‘pacemaker”.

Normal Reabsorption of fluid into the capillary takes place at the arterial end or venous end of the capillary?

The pacemaker action potential is identical to the cardiac contractile cell action potential.

The pulmonary trunk receives blood from the:

The closing of the semilunar valves:

FIND:   Cardiac Output, given that EDV=266 mL;  ESV=104 mL; and HR=110 beats per  minute:

At REST, most of our blood volume lies in the:

Difficulty swallowing: