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Consider the binding site within the muscarinic receptor where the endogenous neurotransmitter Acetylcholine binds. If the structure of Acetylcholine were redrawn properly within the active site, match the functional groups (1-6) to the locations in the binding site (A-F) where they would interact. (hint: rotate, twist, flip, turn the molecule as needed…expand combined functional groups as necessary). Functional Group # Binding Site Location (1) methyl group ? (2) oxygen in carbonyl between (A) and (B) (3) oxygen in ester ? (4) two-carbon spacer between (E) and (F) (5) quaternary amine ? (6) three methyl groups ?   note: Tyr616 has an -OH side chain

Identify the amino acid(s) with a side chain that participates primarily in hydrophobic interactions  at physiological pH (7.4). (select all that apply)

Recalling discussions regarding “what’s in a drug name?”, of the functional groups listed below, select the group(s) that are likely to be present in a drug named DIPHENHYDRAMINE? (select all that apply)

Consider the side chains of the amino acids shown here. Then, complete the statement: *** The strongest form of intermolecular bonding that could take place between the SIDE CHAINS of the amino acids shown is ____.

Identify the amino acid(s) with a side chain that behaves as a BASE at physiological pH (7.4).  (select all that apply)

Consider the panel of amines. For blank 1 – Select the amine group that is likely the WEAKEST hydrogen bond acceptor. [blank1] For blank 2 – Give a BRIEF explanation for your choice (hint: comparison to the others is helpful) [blank2]

What ethical principle binds the health care professional to tell the whole truth regarding a patient’s medical care?

Consider the structure of Vitamin A shown here. Select only the TRUE statement(s). (select all that apply…)

Consider the structure of Vitamin A shown here. Label the statements as either TRUE or FALSE…

A drug classified as a weak unionized base would form a salt with which of the following? (if more than one answer is correct, select all that apply)