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A researcher at a pharmaceutical company is interested in testing out the effects of a new drug, which he thinks will improve attention.  However, he also suspects that the effects of the drug interact with caffeine.  To test this, he tests six separate groups (n = 10, in each group), given either a drug, a placebo, or no drug, and either having consumed caffeine, or no caffeine.  Each performs an attention task.  He collects the following data.   drug placebo no drug Caffeine  x = 5  x = 10  x = 15  x2 = 210  x2 = 330  x2 = 415 No Caffeine  x = 20  x = 10  x = 6  x2 = 780  x2 = 345  x2 = 270 What is the F-value (F-obtained) for the interaction between drug and caffeine (AxB interaction)?

A medicinal chemist needs to determine if the peptide bond found in a potential drug is important for rigidity or hydrogen bond formation. Which of the following substitutions for the peptide (amide) bond will show that rigidity is important?

Cimetidine is an antacid derived from a natural source which is itself derived from an amino acid.  What is cimetidine a derivative of?

Which of the following properties of a drug is most likely to result in a minimum of side effects?

Isoprenaline is an adrenergic agonist. The isoprenaline analogue shown below demonstrates a dramatic increase in activity in in vitro studies. What is the most likely conclusion that can be drawn?   

Which of the following is an enzyme involved in catalyzing Phase II metabolic reactions?

The structure shown has a flexible chain. Which of the following statements is true.  

****BONUS****   What will you take away from this class that you can apply to your career?

A nurse is preparing to administer amoxicillin 30 mg/kg/day divided equally every 12 hr to a toddler who weighs 33 lbs. Available is amoxicillin 200 mg/5 mL suspension. How many mL should the nurse administer per dose? (Round the answer to the nearest tenth)

A 27-year-old male with a T4 spinal cord injury presents to the emergency department with a sudden onset of pounding headache, facial flushing, and a blood pressure of 198/110 mmHg. He appears anxious and diaphoretic above the level of injury, and reports feeling “strange.” He is currently using an indwelling urinary catheter. Clinical Findings: Heart rate: 54 bpm Respirations: 16/min Temperature: 98.9°F (37.2°C) Skin: Flushed upper body, cool lower extremities Urinary catheter tubing appears kinked Bowel sounds present, abdomen slightly distended Select all the actions the nurse should take