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  In the diagram above, there are two hypothetical models for binding of core eukaryotic transcription factors in a previously unstudied organism you discovered. These transcription factors will recruit the RNA polymerase II to begin polymerizing mRNA. In panel A, you see a dimer of protein “X” which associates symmetrically with the DNA and then binds to two polypeptides of the “Y” protein, one on each end. In panel B, there are three proteins “L”, “M” and “N” that bind to the DNA asymmetrically as shown. Your colleague Bill favors model A and your colleague Sally favors model B. Who has the right model and why? What is fundamentally problematic with the other one?

In reactions where an amino acid in a protein is phosphorylated, the substrate that provides the phosphate is generally:  [Q2]

Phosphorylation of RNA Pol II CTD on serine 2 and 7 is required to leave the promoter and enter elongation

Which symptom should the nurse prioritize in a patient with ventricular fibrillation?

Extra Credit Question:  During a staff meeting, which of the following statements by a nurse demonstrates correct understanding of cardiac valve anatomy?

Which task is appropriate for a nurse to delegate to an unlicensed assistive personnel (UAP) when caring for a client with valve disease?

A patient with chronic ischemic heart disease reports chest pain and shortness of breath. Which action should the nurse take first?

Nurses must monitor patients receiving hypotonic solutions because they are at high risk for which condition?  

Fluid restriction is commonly used in patients with hypernatremia

The patient has vancomycin 1,250 mg ordered once daily for an infection. The vancomycin is available in 250 mL of NS and should infuse over 2 hours. Using an IV pump, how many milliliters per hour should the vancomycin be infused? ___________