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This question refers to tumor suppressor genes and oncogenes in cancer. a. What is the fundamental difference between the roles of oncogenes and tumor suppressor genes in cancer progression?b. Which type of gene (oncogene or tumor suppressor gene) does the “two-hit hypothesis” apply to and why?b. Which type of gene (oncogene or tumor suppressor gene) was discovered first, and what factors made this discovery possible earlier in cancer research?d. Provide an example of how both an oncogene and a tumor suppressor gene could work together to drive cancer progression in the same cell.

Acme Company’s direct labor costs are 45% of its total conversion costs. During the current year, Acme’s direct material costs are $180,000 and its manufacturing overhead costs are $68,200. What are the company’s direct labor costs? Round to the nearest whole dollar amount and do not enter a dollar sign or a decimal point (e.g., enter 89, not $89.00).

Acme Company has two manufacturing departments, P and Q, and applies manufacturing overhead using departmental rates based on direct labor hours (DLHs). Here are estimated overhead data for the current year: During the current month, Acme starts and completes Job 71. Direct materials used are $28,800 and direct labor used is $43,000. Job 71 uses 280 DLHs in Department P and 640 DLHs in Department Q. Acme uses the cost-plus pricing method to set selling prices. The markup is 50% of total manufacturing costs. What is Acme’s selling price for Job 71?

Acme Company has two manufacturing departments, P and Q, and applies manufacturing overhead using departmental rates based on direct labor hours (DLHs). Here are estimated overhead data for the current year: During the current month, Acme starts and completes Job 71. Direct materials used are $28,800 and direct labor used is $43,000. Job 71 uses 280 DLHs in Department P and 640 DLHs in Department Q. Acme uses the cost-plus pricing method to set selling prices. The markup is 40% of total manufacturing costs. What is Acme’s selling price for Job 71?  

Acme Company makes and sells a single product called a widget. Acme’s income statement for the current month is as follows: Each widget sells for $150. Variable selling expenses are $8 per widget, and the remainder of the selling expenses are fixed. Variable administrative expenses are 7% of sales revenue, and the remainder of the administrative expenses are fixed. Assume “Y” equals the total selling and administrative expenses and “X” equals the total number of widgets sold. What is the mixed cost formula for total selling and administrative expenses?

Acme Company produces and sells a single product. The relevant range is 200 to 600 units produced and sold per year. If Acme makes and sells 300 units during a year, the total cost per unit is $860. If Acme makes and sells 500 units during a year, the company’s total variable costs are $156,000. What is the per-unit fixed cost if 200 units are produced and sold during a year? Round to the nearest whole dollar amount and do not enter a dollar sign or a decimal point (e.g., enter 89, not $89.00).

Acme Company uses process costing and has three sequential processing departments: Departments A, B, and C. During the current month, the balance of Department B’s beginning work in process (WIP) inventory is $14,800, which includes $7,100 of transferred in costs. During the month, direct material costs added are $15,200, conversion costs incurred are $19,300, and transferred-in costs are $31,500. The balance of Department B’s ending WIP inventory is $16,100. What is the journal entry to record the transfer of units from Department A to Department B during the current month?

Before making its closing entries at the end of the year, Acme Company’s manufacturing overhead account has a debit balance of $26,500. During the year, the total amount of manufacturing overhead applied to jobs is $400,000, of which $280,000 is included in cost of goods sold, $88,000 is included in ending finished goods inventory, and $32,000 is included in ending work in process inventory. Assuming the amount in the manufacturing overhead account is material, the entry to correct the overapplied or underapplied manufacturing overhead will include a:

Acme Company makes the following estimates for the upcoming year: total annual manufacturing overhead costs of $750,000, total annual direct labor hours of 20,000 hours, and total annual machine hours of 40,000 hours. Acme’s direct labor costs are $30 per hour. Which of the following overhead rates accurately reflects Acme’s expected overhead costs? 

Before making its closing entries at the end of the year, Acme Company’s manufacturing overhead account has a debit balance of $29,500. During the year, the total amount of manufacturing overhead applied to jobs is $400,000, of which $280,000 is included in cost of goods sold, $88,000 is included in ending finished goods inventory, and $32,000 is included in ending work in process inventory. Assuming the amount in the manufacturing overhead account is material, the entry to correct the overapplied or underapplied manufacturing overhead will include a: