A 70-year-old woman presents with shortness of breath at res…

A 70-year-old woman presents with shortness of breath at rest over the past 3 days. She has found it difficult to walk short distances due to shortness of breath. Additionally, she is experiencing confusion, orthopnea, nocturnal dyspnea, and lightheadedness. She denies cough, fever, chills, diaphoresis, anxiety, chest pain, pleurisy, nausea, abdominal pain, vomiting, diarrhea, rashes, and syncope. On physical examination, the patient is short of breath, requiring numerous pauses during conversation. She is afebrile, but she is tachycardic, diaphoretic, and her extremities are cool. There is a diminished first heart sound, S3 gallop, laterally displaced PMI, bibasilar rales, and dullness to percussion and expiratory wheezing noted. An elevated JVD and 2+ pitting edema of the lower extremities is evident. What mechanism is primarily responsible for her symptoms?

An 11-month-old girl is noted to have blue lips and some fat…

An 11-month-old girl is noted to have blue lips and some fatigue after running around the room for as little as 4 minutes. The mother reports an uncomplicated, normal delivery. However, as the family has recently immigrated from Mexico, and she has not been evaluated by a doctor or NP in the past. Which of the following is the most likely diagnosis?