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Question from Dr. Srinivas Bharadwaj MCQs Select one from following two questions 19. (2 pts): Autoimmune polyendocrine syndrome, is a condition due to mutation in   (a) AIRE (b) Bcl2 (c) Foxp3 (d) Cbl-B   20. (2 pts): Anergy refers to which of the following (a) Lymphocyte death induced by exposure to antigen (b) Lymphocytes functionally unresponsive to antigen (c) Low production of IgG (d) Poor production of monocolonal antibody

Question from Dr. Srinivas Bharadwaj  Select one from two questions (17 – 18)   21.(a) (5 pts):   What is peripheral tolerance?       (b) (9 pts):  Explain the mechanisms of peripheral tolerance.   ———————————————————————-   22. (a) (5 pts): What is central tolerance?        (b) (9 pts): Explain positive and negative selection with respect to central tolerance. 

Question from Dr. Srinivas Bharadwaj  Select one from two questions (17 & 18)   17. (14 pts): List and discuss briefly what the immunological implications are of a molecular defect which inhibits the functioning of (a) beta-2-microglobulin and (b) TAP (transporter associated protein). That is, what functions of these proteins would be inhibited?   18. (14 pts): Briefly compare and contrast the exogenous and endogenous antigen processing pathways. Give general examples of exogenous and endogenous antigens as well as the types of immune responses they elicit (i.e. antibody, CD4 helper, CD8 cytotoxic).

True or False: Audiences trust a speaker who has source credibility. 

True or False: Dress attire is the first thing audiences notice.

_____________________provides the framework upon which to arrange the elements of your speech in support of your thesis.

What it’s the most rapid intracellular response of all the receptors?

What is the purpose of signal amplification in a signaling pathway?

Exocytosis is the movement of…

What is the key to the kidney’s ability to produce concentrated urine? Briefly describe how this is achieved.