Ms. Smith is 49 years old and sees her PCP for an annual phy…

Ms. Smith is 49 years old and sees her PCP for an annual physical. In addition, she is worried about getting Alzheimer’s because her mother was diagnosed with Alzheimer’s disease (AD) at 78 years of age. Ms. Smith has no memory issues. There are no other family members with AD. She states that she read on the internet that Alzheimer’s is related to the APOE 4 genetic mutation. What is the best explanation for Mr. Smith?