Blog

In zero-order elimination, the amount of drug eliminated does not change with time.

Active transport is one of the mechanisms by which drugs are absorbed into circulation. Which one of the following statements is NOT correct regarding active transport?

From Rosenbaum, the 3 main fluid compartments drugs distribute into are:

A 30-year-old woman is brought to the emergency department with signs of morphine overdose. Talking to her friend, you discover that she had self-administered morphine 6 h ago. You order a blood analysis which reveals the morphine blood level to be 0.25 mg/L. Assuming that the Vdof morphine in this patient is 250 L and the half-life is 3 h, how much morphine did she inject 6 h earlier?

Which cytochrome P450 isoform is involved in the metabolism of the largest number of drugs?

When looking at the Noyes Whitney equation we can see that when oral medications are taken, smaller particles can increase the surface area which increases the dissolution rate (dC/dt) of the drug. This increases the absorption. Which one of these also cause an increase in the dissolution rate?

The PK concentration time profile is different based on the route of administration. Which of the following statements is false? Select all that apply.

Which of the following route of administration is most likely to subject a drug to first-pass effect?

Name 3 electrolytes that we talked about this week in lecture and 1 main function they perform.

Which client has more body fat and therefore less body fluid?