A 63-year-old male presents with extreme fatigue and feeling…

A 63-year-old male presents with extreme fatigue and feelings of malaise. A complete blood count reveals a white blood cell count of 83,000 x109 /L, marked anemia and thromocytopenia.  A bone marrow aspirate revealed hypercellular marrow with 36% blasts. Immunophenotyping is positive for CD13 and CD33, and negative for CD 19, CD20, CD41 and CD61.  Karyotypic yeilds t(8;21) and RUNX1-RUNX1T1 fusion is detected. What is the most likely disorder?

The CBC for a patient shows decreased WBC and RBC values. Ab…

The CBC for a patient shows decreased WBC and RBC values. Abnormal development is noted for a number of cells on the peripheral blood smear. A bone marrow is ordered and provides the following results: Cellularity is decreased, considering the age of the patient Normal M:E ratio Dysplastic changes noted in myelocytic and erythrocytic cell lines.  17% blasts; Auer rods present  

A healthy individual has his blood drawn as a part of a rout…

A healthy individual has his blood drawn as a part of a routine physical.  The laboratorian performing the differential notes a neutrophil with a nucleus that appears dumbbell shaped (bi-lobed). After scanning the entire slide, it appears that the vast majority of neutrophils have the same nuclei. All other leukocytes appear normal.  Which disorder should be confirmed for this patient?