Laura, a 38-year-old female with severe MDD, has been on esc…

Laura, a 38-year-old female with severe MDD, has been on escitalopram for 12 weeks with minimal improvement. Genetic testing shows she has a polymorphism in the BDNF (brain-derived neurotrophic factor) gene, which is linked to poor neuroplasticity and antidepressant response. What treatment approach is most appropriate for Laura?