John, a 38-year-old male with MDD and GAD, has been on sertr…

John, a 38-year-old male with MDD and GAD, has been on sertraline 100 mg daily for 8 weeks. His depressive symptoms have moderately improved, but he reports persistent restlessness, excessive worry, and difficulty sleeping. He also complains of new-onset sexual dysfunction, which is straining his relationship. What is the best pharmacological adjustment?

Sophia is a 54-year-old female with treatment-resistant depr…

Sophia is a 54-year-old female with treatment-resistant depression (TRD). She has tried multiple medications, including sertraline, venlafaxine, and bupropion, at adequate doses and durations without significant improvement. She also has a history of mild renal insufficiency and hypertension, both controlled on medication. She reports fatigue, anhedonia, and difficulty concentrating. Which advanced treatment option would be most appropriate to consider?

Linda, a 50-year-old female with a long-standing history of…

Linda, a 50-year-old female with a long-standing history of GAD, has been stable on venlafaxine for several years. Recently, she started experiencing heightened anxiety, jitteriness, and insomnia. She denies new stressors or medical issues. What is the most likely cause of her symptoms?