Your next patient is a 44-year-old mother of four who report…

Your next patient is a 44-year-old mother of four who reports pain and stiffness in multiple joints that has persisted for the past 8 months. She has a diagnosis of RA, confirmed by lab results and synovial fluid analysis. Which of the following would be considered first-line therapy for the treatment of RA to achieve remission or low disease activity?