BCH4024 F24 OC E2MU 1024 Q39: Common genetic causes of sever…

BCH4024 F24 OC E2MU 1024 Q39: Common genetic causes of severe adult obesity are loss-of-function mutations in the melanocortin signaling pathway. One effect of these mutations are aberrantly low levels of activated protein kinase A in certain cells of the hypothalamus. What type of mutation would most likely produce low levels of activated PKA?