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Pyrazinamide is associated with the following drug interactions:                                             1.   Decreases hepatic metabolism of warfarin; dosage adjustment is necessary2.   Decreases the effectiveness of oral contraceptives by enhancing their metabolism 3.   Decreases urate clearance, thus dosage adjustment of antigout agents necessary4.   Decreases metabolism of alcohol, concomitant use is best avoided5.   Decreases the blood levels of nevirapine, concurrent use is best avoided

Match each one of the following drugs with its indication. 

Match the following anthelmintic drugs with the corresponding mechanism of actions below. Each answer can be used more than once or not at all: 

Emtricitabine should not be withdrawn in patients with HIV and hepatitis B  virus coinfection for the following reasons:                                                   1. There is a risk of bone marrow suppression                                                               2. There is a risk of rebound hepatitis.                                                                                                         3. There is a risk of hypersensitivity reactions                                                                                          4. There is a risk of decreased bone density                                                                                             5. There is a risk of uncontrolled diabetes mellitus 

. Methotrexate is contraindicated in:                                                           Intrathecal useSignificant hepatic impairmentLymphomaCardiovascular diseaseDiabetes

The mechanism of action of clotrimazole is as follows:                                 1. Inhibits epoxidation of squalene in fungi                                                                         2. Disrupts the synthesis of DNA, RNA, and proteins in fungi                                               3. Inhibits fungal cell wall synthesis4. Inhibits ergosterol synthesis in fungi                                                                                 5. Causes disruption of the mitotic spindle and inhibition of fungal mitosis

The following is the drug of choice for severe systemic mycoses such as cryptococcosis:                                                                                          1.   Nystatin2.   Chlorhexidine3.   Terbinafine4.   Griseofulvin5.   Amphotericin B

 13. The following is the mechanism of resistance to amphotericin B:                             1.  As mutations in the gene encoding α- sterol demethylase enzyme                                                                                                                                              2. It occurs if ergosterol binding is impaired.                                                                                           3. It occurs as accumulation of stepwise mutations of the protease gene                                           4. It occurs due to altered fungal DNA polymerase.                                                                                5. It occurs due to a multiple-layered thick cell wall, which may limit drug entry

The following is used in the management of anxiety except:                                         1.        Diazepam2.        Hydroxyzine3.        Phenobarbital4.        Escitalopram5.        Furosemide

The following is a monoamine oxidase inhibitor:                                                                1.        Moclobemide2.        Venlafaxine3.        Citalopram4.        Vortioxetine5.        Reboxetine