A 10-month-old boy is brought to the office by his parents f…

A 10-month-old boy is brought to the office by his parents for a routine visit. There are several small bruises on the knee and buttocks of the child. Upon further questioning of the parents, the mother reveals that the child has just started crawling. The father states that the child is trying to get up while holding the sofa and chairs also but cries after standing for a few minutes and then sit down. On examination, no other bruises are found, and the child is moving all his limbs without any issues except both the knees, which have a restricted range of motion. The child is scoring at the 90th percentile on the growth chart for both height and weight. What is the best initial test in the evaluation of this patient?

BB is a 55 yo male who presents to the clinic with complaint…

BB is a 55 yo male who presents to the clinic with complaints of failure to maintain an erection. He is evaluated for cardiovascular risk and found to be in general good health. He is prescribed Tadalafil (Cialis) for treatment. What is the mechanism of action of tadalafil? 

A 65-year-old man presents to the hospital complaining of le…

A 65-year-old man presents to the hospital complaining of left upper quadrant abdominal pain, and fatigue. He has no previous medical illnesses, and he is only on vitamin supplements that were started by his primary care provider for excessive tiredness. On examination, he looks slightly pale. On abdominal examination, there is massive splenomegaly. Laboratory investigations reveal, hemoglobin 10.8 g/dl, platelets 140000, and white cell count 140000 per microliter. His peripheral smear shows the left shift with promyelocytes, myelocytes, and metamyelocytes. It is decided to send a sample for cytogenetic analysis. What is it most likely to show?