A 68-year-old man is admitted to the ICU with septic shock….

A 68-year-old man is admitted to the ICU with septic shock. He initially presented with hypotension and fever to 102.5°F. After a 3-L normal saline bolus, he continues to be hypotensive and requires pressures. Blood and urine cultures are obtained. The patient is unable to expectorate sputum. The patient’s past medical history is significant for COPD, coronary artery disease, and alcohol abuse. There is alsolocal incidence of cephalosporin-resistant S pneumoniae is >1%. Which of the following is the recommended empiric antibiotic regimen for this patient?