Blog

A patient is purchasing a home self-administered rapid COVID test with a sensitivity of 84% and a specificity of 99%. How is the sensitivity of this test interpreted?

A non-inferiority study compared risankizumab (intervention) to secukinumab (standard of care) for at least 90% improvement in plaque psoriasis symptoms. An NI margin of 12% was used. Risankizumab was found to achieve a 90% symptom improvement in 73.8% of patients and in secukinumab 65.6% of patients.  95%CI 0.8 to 38.8%). Which of the following is the best interpretation of these results. Compared to secukinumab:

Which of the following is a disease-oriented outcome?

The following 4 scenarios are all from double-masked RCTs. Which of the following situations would be at the highest risk for decreased internal validity due to compromised masking?

A study compared an extended interval between zolendronic acid infusions (every 12 weeks) for preventing skeletal lesions among patients with cancer to the standard of care (every 4 weeks). The NI margin was an absolute difference of 0.28% in the skeletal morbidity rate. Which of the following is the null hypothesis for this study?

What is the current labled with a “?” if 6, 8, 3 and 4?

Itepekimab was compared to placebo in a RCT for use in patients with moderate-to-severe atopic dermatitis (i.e. severe skin inflammation and itching). The primary outcome was changes in the Eczema Area and Severity Index (EASI) score which has a minimally clinically important difference of a change in at least 6.6 points. At week 16 in the RCT, itepekimab had a mean decrease in the EASI score of 14.2 points compared to placebo (p=0.12).

A RCT compared occurrence of flares in patients with gout. The results showed febuxostat compared with allopurinol resulted in a HR of 1.07 (95%CI 1.02–1.09). Which of the following statements best describes the interpretation of these results?

A battery with EMF of 30 V and negligible internal resistance is connected to a resistor network as shown. Before the switch is closed, a current is delivered by the battery. After the switch is closed, a current is delivered by the battery. Find

It is estimated that angioedema occurs in approximately 0.1% of patients taking losartan. An investigator would like to identify potential risk factors for patients who experience angioedema while taking losartan. Which of the following study designs would be most appropriate?