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Below is a 2n=4 cell during interphase (G1). Explain the differences if the cell went through mitosis, or meiosis (i.e. the chromosome number at the end of each cell division). Additionally, highlight when (i.e. which phase) nondisjunction would occur that would result in 4 aneuploid gametes. Note: dotted and solid chromosomes are to distinguish homologues.

Which of the following best describes what Enterprise Value represents?

What is enterprise value (EV)?

Which of the following would be considered one of Mendel’s Laws?

Epigenetic changes

Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) has over 15 known genes (most likely in a some kind of pathway) that can cause the disease phenotype: a progressive degeneration of nervous system function. This is an example of:

The following pedigree is for BRAC2 mutation on chromosome 13. Based on your understanding of inheritance, is it dominant or recessive. What is the probability the III-1 (arrow) inherited the BRAC2 mutation? Note: filled in circles represent known cancer victims with the BRAC2 allele. Does inheriting BRAC2 non-functional allele actually cause cancer? Justify your answer.  

1. Explain how a child could have 3 parents. (2 points max) 2. Summarize 1 of the 2 new studies recently published that use pedigrees as a part of their methods. (2 points max) Note: the maximum points you can receive on the exam is 75 points.    

The nucleus of a cell houses all of the genetic material in a cell.

If the probability of a mother inheriting a disease allele from her parents is 1/2 and the probability that she passes it to her child is 1/4. The chance the child will inherit the allele is 3/4. Assume the males are homozygous normal.