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Define Loss of Heterozygosity (LOH) and briefly indicate a general example in which LOH would be detrimental to a person.

Which of the following lines of evidence supports the conclusion that cancer cell phenotypes are recessive?

RB inhibits passage through the R point in the cell cycle when it is hyperphosphorylated.

[A] are enzymes that covalently attach methyl groups to DNA at [B] dinucleotide sequences.

Select each true statement regarding the consequence of Rb binding to E2F.

The levels of pRB protein vary significantly throughout the cell cycle

Which of the following is a marker of breakage-fusion-bridge (BFB) cycles?

Briefly describe the basic molecular mechanism that triggers the barrier that counts cell divisions.

Apoptosis does not occur in cells lacking p53.

Briefly describe one role of the shelterin complex and why it is important.