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CHOOSE THE BEST ANSWER Use the table below to transcribe and translate the following DNA sequence and identify the final polypeptide strand. DNA: 3′ – TTGGGACCACGGAACCGT – 5′

CHOOSE THE BEST ANSWER Use the table below to transcribe and translate the following DNA sequence and identify the final polypeptide strand. DNA: 3′ – TACGGGGGTCCCTTGGCA – 5′

CHOOSE THE BEST ANSWER A mother and her two daughters each develop breast cancer at approximately the same age in their lives. Based on genetic analysis, it is determined that mutations in the BRCA1,  tumor suppressor gene, is responsible for all three instances of cancer. Their specific mutations are presented below (bold base pair). Mother: ATCGCTCCADaughter A: ATCGCTCCADaughter B: ATCGCTCCA Given these data, what is the most likely origin of each daughter’s cancer? Daughter A’s cancer is [answer1] Daughter B’s cancer is [answer2]

CHOOSE THE BEST ANSWER During DNA replication, our cells use the enzyme helicase to “unzip” the two strands that comprise the DNA molecule. To make copies of specific DNA sequences in the lab, scientists use polymerase chain reaction (PCR).  PCR mimics DNA replication in some ways, but not in how the two strands are pulled apart. How are the two strands of DNA unzipped in the lab during PCR? 

CHOOSE THE BEST ANSWER Red-green color blindness in humans is inherited as a recessive X-linked trait. The allele for normal vision is B, and the allele for colorblindness is b. A husband and wife have 2 sons and 2 daughters. One son and one daughter are color blind. What are the genotypes of the parents?

CHOOSE THE BEST ANSWER Which of the following correctly displays the Central Dogma of Biology?

CHOOSE THE BEST ANSWER What is the relationship between the terms “genotype” and “phenotype”?

CHOOSE THE BEST ANSWER The BRCA gene is a tumor-suppressor gene that regulates the cell cycle. Mutations in BRCA are associated with the development of breast cancer.  As a tumor-suppressor gene, how do you expect mutations in BRCA to disrupt the cell cycle?

CHOOSE THE BEST ANSWER Hunter Syndrome is a rare genetic disorder that is inherited as a recessive X-linked trait. The healthy allele is H, and the allele for Hunter Syndrome is h. A husband and wife have 2 sons and 2 daughters. One son and one daughter have Hunter Syndrome. What are the genotypes of the parents?

CHOOSE THE BEST ANSWER FOR EACH QUESTION You have identified the mutation in a p53 gene responsible for an aggressive type of lung cancer. The normal template sequence is on the top, while the mutant template sequence is below. The specific mutation is shown below in red. What type of mutation is it? [answer1] What change does the mutation cause? [answer2] Normal p53 DNA Sequence: 3′ – AAT GCA AAA CCA TTG CCA – 5’Mutant p53 DNA Sequence: 3′ – AAT GCA AAT CCA TTG CCA – 5′