G-protein-coupled receptors (GPCRs) all have a similar struc…

G-protein-coupled receptors (GPCRs) all have a similar structure with ___[1______]_________ transmembrane domains. When a GPCR binds an extracellular signal, an intracellular G protein, composed of _[2_________]________ subunits, becomes activated. When unstimulated, the α subunit is bound to ___[4__________]_____, which is exchanged for ___[5___________]____ upon stimulation. The intrinsic _[6__________]_______ activity of the α subunit is important for inactivating the G protein, as can be __[3]_______ proteins. The α subunits come in different types, for example, Gαs subunits typically activate an effector protein to increase intracellular _[7]______.   Each matched value will only be used once.   guanylyl cyclase            GTPase          adenylyl cyclase phospholipase C           phosphodiesterase      RGS seven                             three               two       ATP GDP                              cAMP              GTP       Ca2+