The following questions refer to the discovery and function…

The following questions refer to the discovery and function of p53. a) Describe the discovery of p53 and its initial identification as a tumor suppressor. b) Explain the central role of p53 as the “Guardian of the Genome” in preventing cancer development. c) What are the types of mutations typically seen in p53 and how do they lead to cancer progression? d) Discuss the dominant-negative effect of p53 mutations in cancer.  

The following questions refer to apoptosis mechanisms and ap…

The following questions refer to apoptosis mechanisms and apoptosis evasion in cancer. a) Describe the key characteristics of apoptosis and how it differs from necrosis. b) How is the extrinsic vs extrinsic pathway of apoptosis activated, describing the key players? c) What is the role of caspases in apoptosis? d) How do cancer cells evade apoptosis through manipulation of apoptotic pathways?