Sickle cell anemia is an autosomal recessive disease caused…

Sickle cell anemia is an autosomal recessive disease caused by a mutation in the gene that encodes the hemoglobin protein that starts being used shortly after birth. Homozygous mutations in this gene lead to the production of mutant hemoglobin protein. When only mutant hemoglobin protein is produced, red blood cells (RBCs) adopt an abnormal sickle shape and their function is impaired. On December 8, 2023 the FDA approved Casgevy to treat sickle cell anemia. Casgevy is the first medical use of the CRISPR-Cas gene-editing system. Casgevy uses CRISPR-Cas9 technology to cut a gene in the genome. What gene is targeted by the Cas9 used in Casgevy?

A patient has arrived to the Emergency Department (ED) after…

A patient has arrived to the Emergency Department (ED) after experiencing an episode of fainting. Per the medical records, this patient has a diagnosis of anorexia nervosa. The patient appears malnourished and significantly underweight for her height. Which of the following assessments is the priority?

At Caterpillar, a leading construction and mining equipment…

At Caterpillar, a leading construction and mining equipment manufacturer, capacity management is crucial for sustaining operations and planning future growth. Given the phases of capacity management discussed, which activities would Caterpillar likely engage in during the medium-range and long-range capacity management phases?   Please select all that apply.