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Lymphocytic malignancy is most often of what origin?

The CBC for a patient shows decreased WBC and RBC values. Abnormal development is noted for a number of cells on the peripheral blood smear. A bone marrow is ordered and provides the following results: Cellularity is decreased, considering the age of the patient Normal M:E ratio Dysplastic changes noted in myelocytic and erythrocytic cell lines.  17% blasts; Auer rods present  

A healthy individual has his blood drawn as a part of a routine physical.  The laboratorian performing the differential notes a neutrophil with a nucleus that appears dumbbell shaped (bi-lobed). After scanning the entire slide, it appears that the vast majority of neutrophils have the same nuclei. All other leukocytes appear normal.  Which disorder should be confirmed for this patient?

Neutrophils observed in the differential of a 14 year old boy demonstrate heavy purplish cytoplasmic granulation with the presence of dohle bodies. Chief complaint listed in the EMR is fever. This trait is indicative of

When the heme ring is broken down in the macrophage, the iron is returned to the erythroid marrow by transferrin and stored in the macrophage as:

Evaluate the peripheral blood smear and selected cell images below. Based on these findings, rank the following tests by order of importance to evaluate the case:  

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A patient presents with easy bruising and petechiae. A CBC shows a low platelet count flagged by the automated analyzer, so a manual platelet count is performed using a hemocytometer for confirmation. A 1:100 dilution of the blood sample is prepared, and platelets are counted in the center square of both sides of the hemocytometer grid. The total platelet count from both center squares is 30 platelets. What is the platelet count in x10⁹/L? Enter the numeric value only.

A 7-year-old child presents with fatigue, pallor, and growth delay. The CBC and peripheral smear results are as follows: WBC Count: 25.0 x 10⁹/L RBC Count: 5.8 x 10⁶/µL Hemoglobin (Hgb): 6.5 g/dL Hematocrit (Hct): 19% MCV: 65 fL MCH: 18 pg MCHC: 30 g/dL RDW: 16.1% Platelet Count: 450 x 10⁹/L NRBCs: 35 per 100 WBCs Peripheral Smear Findings: Microcytic, hypochromic RBCs. Target cells, anisocytosis, poikilocytosis, and basophilic stippling. Numerous NRBCs. Based on the laboratory data and peripheral smear findings, what is the next best step in the workup of this sample?  

When a patient presents with an abnormal platelet count or bizarre platelet morphology, it is essential to evaluate the number and characteristics of megakaryocytes in the bone marrow. Click on the correct cell in the image below to identify a megakaryocyte.