BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer…

BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer cells have an altered metabolism, one that is much more reliant on glycolysis for ATP production, which explains their ability to grow and metastasize. In the 80 years since the “Warburg Hypothesis” was presented, we have learned a lot about the biochemistry of cancer. The following 6 questions are focused on these findings. Another phenotype of many cancer cells is the overexpression of pyruvate dehydrogenase kinase 1(PDK1), the enzyme responsible for phosphorylating the pyruvate dehydrogenase complex. This increase in PDK1 activity would result in which of the following?

BCH4024 OC SP25 E3 Q35: A 7 month-old baby presented with po…

BCH4024 OC SP25 E3 Q35: A 7 month-old baby presented with poor sucking ability and loss of head control and motor skills.  He had poor appetite, vomited frequently, cried continuously, and suffered from episodes of lactic acidosis.  Genetic analyses revealed the child was diagnosed with non-functioning electron transport. Which of the following would be associated with this diagnosis?