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para-fluorophenol will have a pKa that is higher or lower than phenol?

Consider the following reaction catalyzed by an esterase that is a therapeutic target. Which of the reaction species above (0 through 3) is likely to have the most energetically favorable interactions with amino acids in the enzyme active site?                

Consider a molecule A that has 3 chiral centers. How many diastereomers exist for A? think carefully. 

Which of the following analogs of A contains a bioisosteric substitution?

60.  You are in charge of administering a screening test to a large population.  a). under what circumstances would you want to minimize false positive results (name 2 circumstances ONLY). b).  under what circumstances would you want to minimize the false negatives (2 circumstances ONLY).

Which structure is depicted by #2

Identify the writer of the following work: “The Purloined Letter”

Unlike Poe or Dickinson, Whitman was quite involved in the political scene of his time.

According to our textbook this writer led a life which was “the most melodramatic of any of the major American writers” of their generation.

Born into slavery in 1797 in upstate New York, and living all the way through the Civil War era to 1883, this woman would rise to become one of “the nation’s most flamboyant advocates of the rights of African-Americans and women.”