Select four topics investigated in preclinical research from…

Select four topics investigated in preclinical research from the list below and describe them in your response.  1. Pharmacokinetic profile 2. Pharmacodynamic profile 3. Bioavailability and Bioequivalence 4. Acute toxicity 5. Chronic toxicity 6. Reproductive toxicity and teratogenicity 7. Mutagenicity 8. Carcinogenicity 9. Immunotoxicity 10. Local tolerance