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Please ensure that your camera is set up to show your workspace and your face. At this time show the front and back of your scratch paper, periodic table, and naming compounds and solubility rules chart to the camera so I can see that they are not written on. Show your calculator so I can see the type of calculator you are using. Please keep your hands visible in the camera. I understand that they may be out of view when reaching to move to the next question or to use the online calculator but please keep them above the table and do not reach off to the sides.  Now answer the following true or false question to earn a bonus point: I have done the above requirements, read the exam and Honorlock instructions, and understand that failure to follow all instructions will result in a zero on my exam. 

From a sample of 300 items, 12 are found to be defective. The point estimate of the population proportion defective will be:

For this question, please download the provided Excel file containing the raw data. Your final answer should be entered directly below in the answer box. While you do not need to submit the Excel file itself, your step-by-step work in Excel must be clearly visible on your screen recording. I will review the recorded video of your screen to assign partial credit based on your problem-solving process.Q. A hotel manager is concerned about the number of late arrivals among front-desk employees. The attached Excel file, Q22 (v.4).xlsx, reports the number of times each of 12 employees arrived late during the last two-week work period. Construct a 95% confidence interval for the population mean number of late arrivals. Assume that the population distribution is normal.(Round your answer to 4 decimal places.)

Suppose a city mayor wants to estimate the proportion of residents who support a new public transportation plan. The mayor wants the margin of error to be 0.07. Assume a 90% level of confidence. How large of a sample would be necessary if no estimate were available for the proportion of residents supporting the plan?

We tend to check product reviews before making purchases. Assessing the positivity or negativity of reviews often influences our decisions, shaping our buying behavior. This inclination arises from our desire to ensure we make right choices, relying on the insights of others who might possess information we lack. We simply want to be right.

A team studying colorectal cancer notices that CTCF binding at a specific locus is lost in 70% of tumor samples, despite no mutation in the CTCF gene itself. Bisulfite sequencing reveals CpG hypermethylation within the CTCF consensus binding motif at that locus. The region normally serves as a boundary separating the oncogene MYC from a strong enhancer cluster active in intestinal stem cells. What is the most likely mechanism by which this epigenetic change promotes tumorigenesis?

Of the following reader, which one leading to increased translation initiation by binding to the 5’UTR m6A modifications, so that the translation can be initiated even without the cam in 5’UTR.  

A research team is studying a patient with a rare developmental disorder. Genomic sequencing reveals a heterozygous point mutation in the zinc finger domain of CTCF, abolishing its ability to bind DNA at several target loci. The patient exhibits craniofacial abnormalities, intellectual disability, and growth retardation — a phenotype resembling CTCF haploinsufficiency syndrome.   Question Based on the mutation described, which downstream consequence is most directly responsible for the patient’s phenotype?

Which conclusion best explains how silencing is maintained at these loci despite the loss of H3K27me3?

Extended Answer Question: Answer the following in approximately one paragraph (3-5 well-developed sentences).  Your notes and the textbook may be accessed during the answering of this question but our class discussions may not.  Responses will be graded on the accuracy of chemistry terminology used and the quality and completeness of the explanation, including how well ideas are connected and supported. Explain the science and humor of this comic.