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A patient with chronic tension-type headaches asks about first-line treatment. Best recommendation? 

A neonate requires gentamicin dosing. The NP considers: 

Which is a hallmark of CNS drug therapy? 

Which route bypasses first-pass hepatic metabolism? 

A 52-year-old woman with a 25–pack-year history of smoking presents to discuss pharmacologic options for cessation. She reports prior unsuccessful attempts with nicotine replacement therapy. Her past medical history includes type 2 diabetes mellitus and obesity, but no history of seizures, head trauma, or eating disorders. She is not currently depressed but reports mild anhedonia when she has tried to quit in the past. The NP considers starting bupropion SR. Through which primary mechanism does this medication reduce nicotine cravings and withdrawal symptoms? 

A patient on haloperidol develops rigidity, hyperthermia, and autonomic instability. What is the most likely diagnosis? 

A 55-year-old man with resistant depression is prescribed phenelzine. The NP counsels him to avoid foods containing: 

A 38-year-old man with cluster headaches asks about acute therapy. Most effective regimen? 

A patient diagnosed with Parkinson’s Disease develops psychosis being treated with levodopa. Which medication is preferred? 

Which anesthetic route provides profound sensory and motor block but risks hypotension and spinal headache?