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In 2023 Dr. Ke Zhang published another modifier of (G4C2)30 expression in the fly eye. The modifier was an RNAi targeting basket mRNA. Basket protein promotes stress granule assembly. An image from that paper is shown below.  1) Given the above results, you can conclude that an RNAi targeting basket mRNA is a genetic [suppressor]. 2) Given that basket promotes the formation of stress granules, which is the best conclusion from the above results? [SGs_bad]

RNA foci in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), Fragile X-associated Primary Ovarian Insufficiency Syndrome (FXPOI), and C9orf72 ALS/FTD might cause/promote disease through a toxic gain-of-function mechanism. How might RNA foci be toxic? (i.e. What might RNA foci do that is bad for a cell?)  (Please answer in four sentences or less and restrict your answer to ideas discussed in lecture.)

Which international comparison is at the center of that article?

How did Dr. Wassarman model Ataxia Telangiectasia (A-T) in his dominant modifier screen?

Select True or False for each statement below. When glutamate binds to metabotropic glutamate receptors (mGluRs): it triggers a conformation change in the receptor that opens an ion channel and depolarizes the neuron. [false1] it triggers an intracellular signaling cascade that results in the translation of mRNAs in dendrites. [true1] Fragile X Messenger Ribonucleoprotein 1 protein (FMRP) is phosphorylated and de-methylated. [false3] it leads to the assembly of neuronal granules that contain FMRP. [false2]

The article “Why Did Beit She’an Let Betar Win?” discusses:

Fragile X Syndrome is an X-linked dominant disorder. Thus, it can affect males and females. Why are females more variably affected than males, and also generally less affected than males?

RF burns can result from:

What is the main purpose of an intracranial aneurysm clip?

The FDA SAR limits include: