A 71-year-old man with HFrEF presents with nausea, yellow-gr…

A 71-year-old man with HFrEF presents with nausea, yellow-green visual halos, and new-onset ventricular ectopy. He has been compliant with his digoxin therapy and recently had his furosemide dose increased for volume overload. Labs: K⁺ = 2.8 mEq/L, Cr = 1.0 mg/dL. Which factor most likely precipitated his digoxin toxicity? 

A 29-year-old man with a history of intravenous heroin use i…

A 29-year-old man with a history of intravenous heroin use is brought to the ED unresponsive with shallow respirations (RR 6/min) and pinpoint pupils. He receives IV naloxone 0.4 mg, and within minutes he becomes alert but develops severe agitation, diaphoresis, piloerection, tachycardia, hypertension, and nausea. Which best explains this clinical presentation?