The cells that produce sperm in humans contain 46 chromosome…

The cells that produce sperm in humans contain 46 chromosomes. If one of these cells undergoes meiosis to form sperm​ cells, and chromosomal nondisjunction occurs in chromosome 22 during anaphase I meiosis​ I, what is the chromosome number in each of the resulting​ sperm?

A genetic mutation in the PAH gene leads to phenylketonuria…

A genetic mutation in the PAH gene leads to phenylketonuria (PKU), a genetic disorder that affects the body’s ability to break down the amino acid phenylalanine. Without treatment, high levels of phenylalanine in the blood can lead to delayed growth, impaired brain development, seizures and reduced skin pigmentation and among other symptoms. Which of the following best describes the genetic principle illustrated by this condition?