A network meta-analysis comparing the likelihood of various…

A network meta-analysis comparing the likelihood of various classes of antihypertensive medications and the development of depression was conducted. Below is the table of direct and indirect comparisons from the network meta-analysis. Which comparison is an example of incoherence?

Guselkumab was compared to placebo for the treatment of ulce…

Guselkumab was compared to placebo for the treatment of ulcerative colitis in a randomized double-masked controlled trial. At the end of the trial, participants who received guselkumab were 15% more likely to be in remission from their ulcerative colitis (p=0.003). What type of statistical error is the study at risk for?

The following is an excerpt from an abstract. Write the PICO…

The following is an excerpt from an abstract. Write the PICOS: Objective: To assess the efficacy of intranasal midazolam in children with acute seizure when compared to conventional IV benzodiazepine (BDZ). Methods: PubMed, google scholar, websites clinicaltrials.gov and the WHO-international clinical trials registry platform, were searched. Randomized controlled trials comparing intranasal midazolam against IV BDZ in the treatment of acute seizures in pediatric patients followed for at least 24 hours were included. The primary outcome was time to seizure cessation.

A randomized-controlled trial is designed to compare duloxet…

A randomized-controlled trial is designed to compare duloxetine to sertraline for pediatric patients with severe anxiety. The primary outcome is the mean change on the 26-item Social Phobia and Anxiety Inventory for Children. The investigators determined they needed to enroll 160 participants to achieve 80% power to detect a mean change of 10% on the scale between groups using a two-sided alpha level of 0.05. Which of the following scenarios would INCREASE statistical power? (SELECT ALL THAT APPLY)

A randomized controlled trial compared standard duration var…

A randomized controlled trial compared standard duration varenicline use of 3-months to extended-use varenicline of 6-months. The trial randomized 200 patients in each arm. Which statistical test would be most appropriate to test for the difference in baseline systolic blood pressure between groups?

A study compared inhaled fluticasone (n=821), inhaled beclom…

A study compared inhaled fluticasone (n=821), inhaled beclomethasone (n=843), and inhaled budesonide (n=837) for the change in FEV1 among patients with. Which statistical test would be most appropriate to test for statistical significance of FEV1 between groups at the conclusion of the trial?