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Several technical breakthroughs were required for the routine high-resolution structures obtained by cryo-EM. Name three of these discussed in class that enabled high-resolution structure determination, and describe the advantages that each conferred. (6 pts)

Draw the complete and detailed SN2 mechanism, including arrows for electron pushing, transition state, and possible product(s) for the following reaction: (10 points) * Submission must be during exam time*

After obtaining a purified protein, what are the steps of determining a cryo-EM structure (4 pts)? Name two potential issues that could arise in this workflow, and how these could be optimized (2 pts).

Describe why cryo-EM structures, compared to crystallography, may be more relevant to physiology. Also describe the comparative technical advantages (t­­­­wo of each). (8pts)

Citation form is the same as connected speech form.

Which financial ratio shows a company’s ability to cover short-term debts?

What does an income statement report?

If a funeral home buys a hearse with a $40,000 loan and $10,000 cash, what increases?

Operating cash flow results from:

A patient’s blood pressure is monitored by an appropriately positioned arterial catheter transducer.  The transducer is mounted on an IV pole that is not attached to the bed.  The bed is raise to permit routine patient care.  How will this affect the measured blood pressure?   systolic diastolic 1. increased increased 2. increased decreased 3. decreased decreased 4. decreased increased