A novel genetic mutation leads to a deficiency in polyanioni…

A novel genetic mutation leads to a deficiency in polyanionic glycoproteins within the glomerular endothelium and also affects the structural integrity of the glomerular basement membrane (GBM). Based on the properties of the glomerular filtration barrier, which of the following is the most likely consequence?

A patient with uncontrolled diabetes mellitus presents to th…

A patient with uncontrolled diabetes mellitus presents to the emergency room with severe acidosis. Laboratory tests reveal a significantly decreased plasma HCO3-. To further characterize the metabolic acidosis, which additional diagnostic parameter would be most crucial, and what would its finding likely suggest in this specific case?